Who we are
Abiel (Biomedical and Industrial Applications of Lytic Enzymes) is a ground breaking Biotechnology Company founded in as a spin-off of the National Council of Research (CNR) and the University of Palermo.
Abiel is composed by a multidisciplinary team of qualified scientists and professionals with expertise in enzymology, biochemistry, cell biology and biomarine sciences.
Abiel strives in developing high quality lytic enzymes to help advances in cell isolation for regenerative medicine and cell therapy applications.
Giulio is expert in enzymology and biochemistry with international background including post-doc at the University of Georgetown in Washington, USA. He is author of important articles published in prestigious scientific journals and speaker in many conferences on the topic of proteolytic enzymes. He is currently Professor of Biochemistry at University of Palermo.
Monica is skilled in proteolytic enzymes and human collagenases, having spent a relevant part of her studies in USA, at the Lombardi Cancer Center. She also spent time in Miami at the Diabetes Research Institute, University of Miami Miller School of Medicine, where she was updated on the techniques of Langherans’s islets extraction, purification and related techniques.
Salvatore has over 30 years’ experience in the pharmaceutical industry and a long track record on marketing and BD of biomedical drugs. Salvatore is graduated magna cum laude in Organic Chemistry at the University of Catania and holds a BSc in Pharmacy.
Danilo holds a BSc in Economics from University of Naples, a Master degree in Internet Business from SDA Bocconi. His main expertise is in business modeling and early-stage financing of technology businesses. He has managed and coordinated several EU and national R&D funded projects with first-class partners. He also sits in several boards of Med-Tech and ICT companies.
Paolo is graduated in Biotechnology at University of Palermo. He is an expert in molecular microbiology with specific skills in genetic manipulation, bioinformatics and molecular biology.
What we do
Abiel is a biotechnology company consisting of a multidisciplinary team of qualified scientists and professionals.
The company is engaged in R&D, both in the production and commercialization of innovative high-quality lytic enzymes for tissue dissociation in cell therapy and regenerative medicine applications, and in fermenter synthesis processes for pre-industrial, scalable, production of protein constructs for application in different fields.
Abiel has a know-how to produce proteins through DNA recombinant technologies and specifically is the owner of and International patent for the production of collagenases produced by this method .
In the area of regenerative/replacement medicine, Abiel’s recombinant collagenases represent a step forward towards the optimization and standardization of cell isolation protocols.
We currently offer services in the field of lytic enzymes and regenerative medicine, in particular screening and characterization of lytic enzymes, design and development of new recombinant proteins, ex vivo animal models for the selection of tissue dissociation enzymes.
Over the years, Abiel has developed synthesis processes through which it is possible to obtain high quantities of recombinant proteins, with significant reductions in production costs. The developed technology uses Fed-batch fermentation processes with optimized synthesis parameters, which allow to obtain in the order of 1.5 – 2.0 gr/L of recombinant protein fermentate, through IPTG induction with a yield between 40% and 60%compared to the total proteins. It has also developed purification procedures up to 90% and more, through chromatographic systems and tangential flow filtration (TFF). Last but not least, their concentration (in relation to their solubility) and freeze-drying in controlled conditions.
Address
via Enzo ed Elvira Sellerio n. 50
90141 Palermo, Italy
Phone
+39 339 438 5155
Fax: +39 0916615628